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The use of Prograf in liver transplant recipients experiencing post-transplant hepatic impairment may be associated with increased risk of developing renal insufficiency related to high whole-blood concentrations of tacrolimusThese patients should be monitored closely and dosage adjustments should be consideredSome evidence suggests that lower doses should be used in these patientssee Dosage In Adult KidneyLiverOr Heart Transplant PatientsUse in Specific Populations and CLINICAL PHARMACOLOGY

Before you take PROGRAFtell your healthcare provider about all of your medical conditionsincluding if youplan to receive any live vaccinespeople taking PROGRAF should not receive live vaccineshave or have had liverkidney or heart problems are pregnant or plan to become pregnantPROGRAF can harm your unborn babyIf you are able to become pregnantyou should use effective birth control before and during treatment with PROGRAFTalk to your healthcare provider before starting treatment with PROGRAF about birth control methods that may be right for youMales who have female partners who are able to become pregnant should also use effective birth control before and during treatment with PROGRAFTalk to your healthcare provider before starting treatment with PROGRAF about birth control methods that may be right for youare breastfeeding or plan to breastfeedPROGRAF passes into your breast milkYou and your healthcare provider should decide if you will breastfeed while taking PROGRAF.

Ask your healthcare provider or pharmacist if you are not sure if you take any of the medicines listed abovePROGRAF may affect the way other medicines workand other Femcare order medicines may affect how PROGRAF worksKnow the medicines you takeKeep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.

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