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When therapeutic response is evidentconsideration should be given to reducing the maintenance dosage to the lowest level compatible with the maintenance of that responseIf no improvement occurs in the patient’s condition within 3 monthsconsideration should be given to withdrawing Imuran.

Using Imuran for a long time may increase your risk of skin cancer and lymphomaLymphoma is a cancer that affects your immune cells.

As there is in vitro evidence that aminosalicyclate derivatives(egolsalazinemesalazine or sulphasalazineinhibit the TPMT enzymethey should be administered with caution to patients receiving concurrent Imuran therapysee 4.4 Special Warning and Special Precautions for Use

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